“(Neo)blast from the past: new insights into planarian stem cell lineages”

Shujun Zhu and Bret J Pearson

Current Opinion in Genetics and Development 40:74-80

“Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias”

Bradford M Stubenhaus, John P Dustin, Emily R Neverett, Megan S Beaudry, Leanna E Nadeau, Ethan Burk-McCoy, Xinwen He, Bret J Pearson, and Jason Pellettieri

eLife 5:e14175

“In silico lineage tracing through single cell transcriptomes identifies a neural stem cell population in planarians”

Alyssa M. Molinaro and Bret J. Pearson

Genome Biology 17:87, doi: 10.1186/s13059-016-0937-9

“HOX complement and expression in the planarian Schmidtea mediterranea

Currie, KW, Brown, DDR, Zhu, SJ, Xu, C, Voisin, V, Bader GD and Pearson BJ

EvoDevo 7:7 doi:10.1186/s13227-016-0044-8.


“A mex3 homolog is required for differentiation during planarian stem cell lineage development”

Shu Jun Zhu, Stephanie E Hallows, Ko W Currie, ChangJiang Xu, Bret J Pearson

eLife 4:e07025

“One FISH, dFISH, three FISH: Sensitive methods of whole-mount fluorescent in situ hybridization in freshwater planarians”

David D. R. Brown and Bret J Pearson

Book Chapter: In situ hybridization methods: Neuromethods 99:127-150, Springer Science

“A conserved requirement for the Mediator component Med14 in the maintenance of stem cell populations”

Burrows, JTA, Pearson, BJ, and Scott, IC

Stem Cell Reports 4:670-684.


Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion”

Jared A. Talbot, Ko W. Currie, Bret J. Pearson and Eva-Maria S. Collins

Biology Open 3:627-634.

“Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning”

Alexander Y.T. Lin and Bret J. Pearson

Development 141(6):1197-208.


“Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis”

Martis W. Cowles, David D.R. Brown, Sean V. Nisperos, Brianna N. Stanley, Bret J. Pearson, and Ricardo M. Zayas

Development 140:4691-4702.

“Cilia-driven locomotion in planarians requires serotonergic neurons specified by lhx1/5-1 and pitx transcription factors”

Ko W. Currie and Bret J. Pearson

Development 140:3577-3588.


“The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians”

Shu Jun Zhu and Bret J. Pearson

Developmental Biology 373:442-453.

“A Comparative Transcriptomic Analysis Reveals Conserved Features of Stem Cell Pluripotency in Planarians and Mammals”

Labbé RM, Irimia M, Currie KW, Lin A, Zhu SJ, Brown DD, Ross EJ, Voisin V, Bader GD, Blencowe BJ, Pearson BJ.

Stem Cells 30(8):1734-45.

“Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms”

Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ, Moran MF.

Molecular and Cellular Proteomics 11(9):681-91

“TORC1 is required to balance cell proliferation and cell death in planarians”

Tu KC, Pearson BJ, Sánchez Alvarado A.

Developmental Biology 365(2):458-69.


“A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages”

Pearson BJ and Sánchez Alvarado A.

Development 137(2):213-21.


“Formaldehyde-based whole-mount in situ hybridization method for planarians”

Pearson BJ, Eisenhoffer GT, Gurley KA, Rink JC, Miller DE, Sánchez Alvarado A.

Developmental Dynamics 238(2):443-50.

“Regeneration, stem cells, and the evolution of tumor suppression”

Pearson BJ, Sánchez Alvarado A.

Cold Spring Harb Symp Quant Biol 73:565-72.


“Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling”

Oviedo NJ, Pearson BJ, Levin M, Sánchez Alvarado A.

Disease Models and Mechanisms 1(2-3):131-43.


“Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened”

Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M.

Developmental Biology 297(1):127-40.


“Regulation of temporal identity transitions in Drosophila neuroblasts”

Grosskortenhaus R, Pearson BJ, Marusich A, Doe CQ.

Developmental Cell 8(2):193-202.


“Specification of temporal identity in the developing nervous system”

Pearson BJ and Doe CQ.

Annu Rev Cell Dev Biol 20:619-47.

“Molecular characterization, functional expression and tissue distribution of a second NCKX Na+/Ca2+ -K+ exchanger from Drosophila”

Winkfein RJ, Pearson B, Ward R, Szerencsei RT, Colley NJ, Schnetkamp PP.

Cell Calcium 36(2):147-55.


“Regulation of neuroblast competence in Drosophila”

Pearson BJ and Doe CQ.

Nature 425(6958):624-8.


“Potassium-dependent sodium-calcium exchange through the eye of the fly”

Webel R, Haug-Collet K, Pearson B, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ.

Ann N Y Acad Sci 976:300-14.


“Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny”

Isshiki T, Pearson B, Holbrook S, Doe CQ.

Cell 106(4):511-21.

“The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans”

Pierce-Shimomura JT, Faumont S, Gaston MR, Pearson BJ, Lockery SR.

Nature 410(6829):694-8.


“Cloning and characterization of a potassium-dependent sodium/calcium exchanger in Drosophila”

Haug-Collet K, Pearson B, Webel R, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ.

Journal of Cell Biology 147(3):659-70.

“Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution”

Keys DN, Lewis DL, Selegue JE, Pearson BJ, Goodrich LV, Johnson RL, Gates J, Scott MP, Carroll SB.

Science 283(5401):532-4.

Full List on PubMed

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